USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

USC-OGP 2-DE database  Search by                Maps             Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal World-2DPAGE Repository Exclude local DBs has only effect if a remote interface is selected

Searching in 'USC-OGP 2-DE database' for entry matching: PAK2_HUMAN USC-OGP 2-DE database:  PAK2_HUMAN PAK2_HUMAN General information about the entry View entry in simple text format Entry name PAK2_HUMAN Primary accession number Q13177 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Serine/threonine-protein kinase PAK 2; EC=2.7.11.1; AltName: Full=Gamma-PAK; AltName: Full=PAK65; AltName: Full=S6/H4 kinase; AltName: Full=p21-activated kinase 2; Short=PAK-2; AltName: Full=p58; Contains: RecName: Full=PAK-2p27; Short=p27; Contains: RecName: Full=PAK-2p34; Short=p34; AltName: Full=C-t-PAK2;. Gene name Name=PAK2 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_4-7 {PLATELET 4-7} Homo sapiens (Human)   map experimental info   PLATELET_4-7 MAP LOCATIONS: SPOT OGP-0336: pI=5.58; Mw=60151 UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1137: pI=5.70; Mw=62554 SPOT OGP-1138: pI=5.84; Mw=62554 Cross-references UniProtKB/Swiss-Prot Q13177; PAK2_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name PAK2_HUMAN Primary accession number Q13177 Secondary accession number(s) Q13154 Q6ISC3 Sequence was last modified on  April 3, 2007 (version 3) Annotations were last modified on  March 15, 2017 (version 185) Name and origin of the protein Description RecName: Full=Serine/threonine-protein kinase PAK 2; EC=2.7.11.1; AltName: Full=Gamma-PAK; AltName: Full=PAK65; AltName: Full=S6/H4 kinase; AltName: Full=p21-activated kinase 2; Short=PAK-2; AltName: Full=p58; Contains: RecName: Full=PAK-2p27; Short=p27; Contains: RecName: Full=PAK-2p34; Short=p34; AltName: Full=C-t-PAK2; Gene name Name=PAK2 Encoded on Name=PAK2 Keywords 3D-structure; Acetylation; Allosteric enzyme; Apoptosis; ATP-binding; Complete proteome; Cytoplasm; Direct protein sequencing; Growth regulation; Host-virus interaction; Kinase; Lipoprotein; Membrane; Myristate; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase; Ubl conjugation. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL U24153; AAA65442.1; -; mRNA EMBL BC069613; AAH69613.1; -; mRNA EMBL U25975; AAA75468.1; -; mRNA CCDS CCDS3321.1; -; . PIR S58682; S58682; . RefSeq NP_002568.2; NM_002577.4; . RefSeq XP_011511172.1; XM_011512870.2; . RefSeq XP_016861990.1; XM_017006501.1; . UniGene Hs.518530; -; . PDB 3PCS; X-ray; 2.86 A; E/F/G/H=121-136 PDBsum 3PCS; -; . ProteinModelPortal Q13177; -; . SMR Q13177; -; . BioGrid 111098; 84; . DIP DIP-38249N; -; . IntAct Q13177; 47; . MINT MINT-235655; -; . STRING 9606.ENSP00000314067; -; . BindingDB Q13177; -; . ChEMBL CHEMBL4487; -; . GuidetoPHARMACOLOGY 2134; -; . iPTMnet Q13177; -; . PhosphoSitePlus Q13177; -; . SwissPalm Q13177; -; . BioMuta PAK2; -; . DMDM 143811432; -; . OGP Q13177; -; . EPD Q13177; -; . MaxQB Q13177; -; . PaxDb Q13177; -; . PeptideAtlas Q13177; -; . PRIDE Q13177; -; . DNASU 5062; -; . Ensembl ENST00000327134; ENSP00000314067; ENSG00000180370; . GeneID 5062; -; . KEGG hsa:5062; -; . UCSC uc003fwy.4; human; . CTD 5062; -; . DisGeNET 5062; -; . GeneCards PAK2; -; . H-InvDB HIX0030815; -; . HGNC HGNC:8591; PAK2; . HPA CAB007794; -; . MIM 605022; gene; . neXtProt NX_Q13177; -; . OpenTargets ENSG00000180370; -; . PharmGKB PA32918; -; . eggNOG KOG0578; Eukaryota; . eggNOG ENOG410XP4K; LUCA; . GeneTree ENSGT00860000133680; -; . HOGENOM HOG000234202; -; . HOVERGEN HBG108518; -; . InParanoid Q13177; -; . KO K04410; -; . OMA MTSASHK; -; . OrthoDB EOG091G04H8; -; . PhylomeDB Q13177; -; . TreeFam TF105351; -; . BRENDA 2.7.11.1; 2681; . Reactome R-HSA-164944; Nef and signal transduction; . Reactome R-HSA-202433; Generation of second messenger molecules; . Reactome R-HSA-211728; Regulation of PAK-2p34 activity by PS-GAP/RHG10; . Reactome R-HSA-211733; Regulation of activated PAK-2p34 by proteasome mediated degradation; . Reactome R-HSA-211736; Stimulation of the cell death response by PAK-2p34; . Reactome R-HSA-2871796; FCERI mediated MAPK activation; . Reactome R-HSA-389359; CD28 dependent Vav1 pathway; . Reactome R-HSA-3928664; Ephrin signaling; . Reactome R-HSA-399954; Sema3A PAK dependent Axon repulsion; . Reactome R-HSA-428540; Activation of Rac; . Reactome R-HSA-4420097; VEGFA-VEGFR2 Pathway; . Reactome R-HSA-5218920; VEGFR2 mediated vascular permeability; . Reactome R-HSA-5621575; CD209 (DC-SIGN) signaling; . Reactome R-HSA-5627123; RHO GTPases activate PAKs; . Reactome R-HSA-5687128; MAPK6/MAPK4 signaling; . SignaLink Q13177; -; . SIGNOR Q13177; -; . ChiTaRS PAK2; human; . EvolutionaryTrace Q13177; -; . GeneWiki PAK2; -; . GenomeRNAi 5062; -; . PMAP-CutDB Q13177; -; . PRO PR:Q13177; -; . Proteomes UP000005640; Chromosome 3; . Bgee ENSG00000180370; -; . CleanEx HS_PAK2; -; . ExpressionAtlas Q13177; baseline and differential; . Genevisible Q13177; HS; . GO GO:0005737; C:cytoplasm; IDA:BHF-UCL; . GO GO:0005829; C:cytosol; TAS:Reactome; . GO GO:0005634; C:nucleus; IEA:UniProtKB-SubCell; . GO GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell; . GO GO:0005886; C:plasma membrane; TAS:Reactome; . GO GO:0005524; F:ATP binding; IEA:UniProtKB-KW; . GO GO:0045296; F:cadherin binding; IDA:BHF-UCL; . GO GO:0042802; F:identical protein binding; IPI:IntAct; . GO GO:0004672; F:protein kinase activity; TAS:ProtInc; . GO GO:0019901; F:protein kinase binding; IPI:BHF-UCL; . GO GO:0004674; F:protein serine/threonine kinase activity; IDA:BHF-UCL; . GO GO:0030296; F:protein tyrosine kinase activator activity; IDA:BHF-UCL; . GO GO:0004702; F:signal transducer; downstream of receptor; with serine/threonine kinase activity IBA:GO_Central . GO GO:0006915; P:apoptotic process; IEA:UniProtKB-KW; . GO GO:0071407; P:cellular response to organic cyclic compound; IEA:Ensembl; . GO GO:0060996; P:dendritic spine development; IEA:Ensembl; . GO GO:0038095; P:Fc-epsilon receptor signaling pathway; TAS:Reactome; . GO GO:0043066; P:negative regulation of apoptotic process; IMP:UniProtKB; . GO GO:2001271; P:negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis; IDA:UniProtKB; . GO GO:0006469; P:negative regulation of protein kinase activity; TAS:ProtInc; . GO GO:0018105; P:peptidyl-serine phosphorylation; IDA:BHF-UCL; . GO GO:0016310; P:phosphorylation; IDA:UniProtKB; . GO GO:2001238; P:positive regulation of extrinsic apoptotic signaling pathway; IMP:UniProtKB; . GO GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IDA:BHF-UCL; . GO GO:0046777; P:protein autophosphorylation; IDA:MGI; . GO GO:0006468; P:protein phosphorylation; IDA:MGI; . GO GO:0050690; P:regulation of defense response to virus by virus; TAS:Reactome; . GO GO:0040008; P:regulation of growth; IEA:UniProtKB-KW; . GO GO:0007165; P:signal transduction; TAS:ProtInc; . GO GO:0002223; P:stimulatory C-type lectin receptor signaling pathway; TAS:Reactome; . GO GO:0031295; P:T cell costimulation; TAS:Reactome; . GO GO:0050852; P:T cell receptor signaling pathway; TAS:Reactome; . GO GO:0048010; P:vascular endothelial growth factor receptor signaling pathway; TAS:Reactome; . GO GO:0016032; P:viral process; IEA:UniProtKB-KW; . CDD cd01093; CRIB_PAK_like; 1; . Gene3D 3.90.810.10; -; 1; . InterPro IPR000095; CRIB_dom; . InterPro IPR011009; Kinase-like_dom; . InterPro IPR033923; PAK_BD; . InterPro IPR000719; Prot_kinase_dom; . InterPro IPR017441; Protein_kinase_ATP_BS; . InterPro IPR008271; Ser/Thr_kinase_AS; . Pfam PF00786; PBD; 1; . Pfam PF00069; Pkinase; 1; . SMART SM00285; PBD; 1; . SMART SM00220; S_TKc; 1; . SUPFAM SSF56112; SSF56112; 1; . PROSITE PS50108; CRIB; 1; . PROSITE PS00107; PROTEIN_KINASE_ATP; 1; . PROSITE PS50011; PROTEIN_KINASE_DOM; 1; . PROSITE PS00108; PROTEIN_KINASE_ST; 1; .

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